GLP-1 - Ofer Nave

# Medical > GLP-1 *See also: [[Nutrition]]* A family of medications that suppress hunger. - Also slows down digestion so food sticks around longer. | | Ingredient | Agonist | Half-Life | Brands | | :-: | :---------: | :--------------------: | :-------: | :-----------------------: | | v1 | Semaglutide | GLP | | Ozempic, Rybelsus, Wegovy | | v2 | Tirzepatide | GLP-1 + GIP | 5 days | Monjauro, Zepbound | | v3 | Retatrutide | GLP-1 + GIP + glucagon | | *coming soon* | > [!NOTE] Half-Lifes > 4x half-life = full elimination ## Tirzepatide #### Experience - Generally don't feel hungry or think about food. - Not unpleasant to eat. Food tastes the same, but doesn't trigger overpowering cravings. #### Usage - Weekly injections — delivered either as pre-loaded syringes (sometimes in plastic "pen"-style housing to make it less scary) or in the form of bottles + package of new syringes. - Injections are subcutaneous, which are easy to do / hard to screw up, and don't hurt much. - Effects kick in as soon as a few hours later, but take 24-48hrs to reach full strength — and then wane near the end of the 7-day cycle. - Resistance builds, so dosage must be increased periodically. - You can pause / delay the next shot whenever you like for as long as you like, such is if you want to enjoy eating more on a vacation, or to drop your resistance back down to reduce the needed dose when you resume. > [!NOTE] Understanding Labels > 1 unit = 0.01mL. If a bottles contains 2mL of liquid, that's' 200 units. A typical syringe can draw 60-100 units (0.6-1.0 mL). ###### Anecdotal Effectiveness Chart | When | Effectiveness | | ------------------ | :-----------: | | @ Injection | 0% | | Injection + 1 day | 80-100% | | Injection + 2 days | 100% | | Injection + 3 days | 100% | | Injection + 4 days | 97% | | Injection + 5 days | 90% | | Injection + 6 days | 80% | | Injection + 7 days | 50% | #### Injection Tips - Rotate injection sites each week to avoid irritation or tissue damage. - Abdomen: At least 2 inches away from the belly button, as this area has a good layer of fat for absorption. - Thigh: The upper, outer part of the thigh, where there’s enough subcutaneous tissue. - Upper arm: The back or outer part of the upper arm, though this may be harder to self-inject without assistance. - Avoid injecting into areas that are bruised, tender, scarred, or near moles or tattoos. - Clean the site with an alcohol swab before injecting. (Also clean the needle.) See also: [Where to inject for MAXIMUM GLP-1 Weight Loss](https://youtube.com/watch?v=RMFifEo3lfw) #### Lifestyle Tips - Drink lots of water. - Get lots of soluable fiber — 25g for women, 38g for men. *([pills](https://amazon.com/dp/B003VV05IM/), oats, beans, chia seeds)* - Eat mostly protein — at least 1g / kg of body weight — up to 1.6g / kg if you can. - Eat small amounts frequently throughout the day to keep metabolism active. - Lift heavy weights to increase or at least retain muscle. - Don't go too fast for too long — go slow or take breaks for skin to heal / shrink. > [!NOTE] Traveling > Tirzepatide is shelf stable for 21 days, so you can safely travel with it on long flights. [Syringes are allowed on flights](https://www.tsa.gov/travel/security-screening/whatcanibring/items/unused-syringes. ## Market Internet companies partner with doctors to issue prescriptions to online customers, and partner with real-world pharmacies (usually near the internet company) to prepare the medicine. An online search for "tirzepatide" will produce dozens of results of simple marketing-heavy websites that look scammy, but are actually legitimate. *(At least, I haven't personally encountered fraud yet, either myself or through my social network.)* If you're getting a medicine that has not yet been approved purely for weightloss, such as Tirzepatide, pharmacies will mix it with vitamins and other beneficial ingredients in order to pass legal muster. | Website | Notes | | ----------------------------------------------------------------- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | [BrelloHealth.com](BrelloHealth.com/product/tirzepatide-b6) | $499 for 3 months (autorenews after 10 weeks) | | [Lilly.com](https://www.lilly.com/lillydirect/medicines/zepbound) | 2.5mg $349 5.0mg $499 If refill not ordered within 45d of prev month's delivery: 7.5mg $499 or $599 10.0mg $499 or $699 12.5mg $499 or $849 15.0mg $499 or $1,049 | | [MediVeraRx.com](MediVeraRx.com) | it's all very confusing injection 2.0ml $250 7-2 (7mg tirzepatide + 2mg vitamins) 2.5ml $300 8-2 4.0ml $375 17-2 drops 10mg $199 25mg $450 Process: have dr send prescription, they call me within 48hrs | | [MultiMedRx.com](MultiMedRx.com) | $50-100 online consult for prescription no price details for medicine | | [OhMyMeds.com](OhMyMeds.com) | $350/mo (monthly) $250/mo (3mo, paid up-front?) $225/mo (6mo, paid up-front?) $200/mo (12mo) | | [PriorityMeds.com](PriorityMeds.com) | $195.82/month - "no hidden fees" | | [Vitastir.com](Vitastir.com/product/tirzepatide/) | 2.5mg $189 5.0mg $299 7.5mg $399 10.0mg $449 12.5mg $499 15.0mg $599 | ## References - [How does Zepbound (tirzepatide) compare to Wegovy (semaglutide)?](https://youtube.com/watch?v=tcD8RHx5hhI) - [GLP-1 Diet MISTAKE 90% Are Making (Fix This Now)](https://youtube.com/watch?v=2ak_pP0T0Uo) - [9 Things You Should NEVER Do on Ozempic or Zepbound](https://youtube.com/watch?v=BVKR8Ds4Ito) - [10 Reasons You Are NOT Losing Weight On GLP-1s](https://youtube.com/watch?v=l_FKyL0rsTg) - [Everything you need to know about Retatrutide, the newest GLP1 agonist](https://youtube.com/watch?v=r1AfHN4hgjQ)